Variabilidade da frequência cardíaca nos domínios do tempo, da frequência e da não-linearidade em pacientes com hiperidrose primária focal

Abstract

The human skin is 15% of the total body weight and has a vital function to promote the homeostasis of the organism by means of thermoregulation, hemodynamic control, production and excretion of metabolites. Hyperhidrosis (HH) is a pathological condition in which sweat production by the sweat glands is increased beyond the normal physiological needs of the body required to maintain thermo homeostasis. The pathophysiology of Focal Primary Hyperhidrosis (HHPF) remains poorly understood despite suggesting evidence of the occurrence of hyperactivity of the sympathetic nervous system. Objective: To investigate the functions of the Autonomic Nervous System (ANS), in patients with HHPF compared to a control group, apparently healthy, matched by gender, age and body mass index, using the HRV analysis in the time domain, frequency and nonlinearity. Material and Methods: 34 patients with primary hyperhidrosis focal, and the control group of 34 subjects were submitted to analysis of HRV in the time domain, frequency and non-linearity and the results were compared. Results: HRV parameters including mean RR, SDNN, RMSSD, PNN50, low frequency (LF) and high frequency (HF), did not show any difference between the two groups. The same occurred in the nonlinear domain, the SD1 parameters, SD2, ApEn, RP_Lmean% and REC. Conclusion: The findings suggest that the pathophysiology of the Focal Primary Hyperhidrosis , may be due to the peripheral involvement of the sympathetic nervous system (glandular level or nerve endings) since there was no difference between groups. More specific studies should help to elucidate the problem.